Cribbed from the Globe and Mail who cribbed it from Rebecca Coffey, a nice Irish girl I am sure, who writes for Discover magazine, this is all about sweeteners but all about scientists with a bit of a deathwish.
Both saccharin and aspartame were discovered when lab workers doing research that had nothing to do with sweetening decided to put a bit of the compounds in their mouths and liked what they tasted.
Better/scarier story about the discovery of sucralose, brand name Splenda. The scientists working on that chemical concoction were trying to create a bug killer. An assistant, a scientist, bear that in mind, was told to test the compound. He heard the word taste. When he didn't die, they packaged it as a sweetener.